Reply to Brewer: Liver-targeted ALDH2 inhibition may reduce alcohol-seeking behaviors with limited side effects

We are pleased to read the Letter from Dr. Brewer (1) on our paper in PNAS (2). In our manuscript, we only briefly discuss our current knowledge about aldehyde dehydrogenase 2 (ALDH2) inhibition therapy for the treatment of alcohol user disorder (AUD) due to space limitation. We greatly appreciate Dr. Brewer for elaborating on previous findings in the area of ALDH2 inhibition therapies that were tested both in patients and in animal models (1). It is true that the effects of ALDH2 genotype on alcohol-seeking behavior have been well documented (3) and many drugs that … [↵][1]2To whom correspondence may be addressed. Email: bgao{at}mail.nih.gov. [1]: #xref-corresp-1-1