Does the P 2X1del variant lacking 17 amino acids in its extracellular domain represent a relevant functional ion channel in platelets

In a recent issue of Blood, Greco et al[1][1]reported on the expression of a novel structurally altered P2X1 receptor in platelets and in megakaryocytic cell lines. This P2X1 variant lacks 17 amino acids in its extracellular domain due to a deletion within exon 6 of the P2X1 gene (GenBank accession