FGF signals specifically regulate the structure of hair shaft medulla via IGF-binding protein 5
2005
Reciprocal interactions between the dermal papilla and the hair matrix
control proliferation and differentiation in the mature hair follicle.
Analysis of expression suggests an important role for FGF7 and FGF10, as well
as their cognate receptor FGFR2-IIIb, in these processes. Transgenic mice that
express a soluble dominant-negative version of this receptor in
differentiating hair keratinocytes were generated to interfere with endogenous
FGF signalling. Transgenic mice develop abnormally thin but otherwise normal
hairs, characterised by single columns of medulla cells in all hair types. All
structural defects and the accompanying changes of global gene expression
patterns are restricted to the hair medulla. Forced transgenic expression of
IGF-binding protein 5, whose expression level is elevated upon suppression of
FGFR2-IIIb-mediated signalling largely phenocopies the defect of
dnFgfr2-IIIb -expressing hairs. Thus, the results identify
Igfbp5 -mediated FGFR2-IIIb signals as a key regulator of the genetic
program that controls the structure of the hair shaft medulla.
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