Changes in Some Red Cell Enzymes, Coagulation and White Cell Parameters in Relation to CD4 Count Values in HIV Subjects

Aim: To assess the effect of CD4 count stage of HIV positive patients on antiretroviral treatment (ART) and those not on antiretroviral treatments on G-6-PD, Pyruvate kinase enzyme activity, some coagulation and white cell parameters. Study Design: Case-control study Place of Study: Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria. Methodology: We included 181 subjects; Sixty HIV patients on ART; Sixty HIV patients not on ART and Sixty-one apparently healthy individual control. Glucose-6-Phosphate Dehydrogenase (G-6-PD) activity, Pyruvate kinase (PK) activity, Activated Partial Thromboplastin time (APTT), Prothrombin time (PT), Platelet count (PLT), CD4 count, total white cell count (TWBC), differential WBC count (NEUT, LYM and MXD) and Human Immunodeficiency virus (HIV) status were determined. Results: In ART subjects, APTT and PT were significantly prolonged in subjects with CD4 count 0.05). In non-ART, G-6-PD activity was significantly lower in subjects with CD4 count 0.05). Conclusion: This study showed that in ART subjects, APTT, PT, TWBC and LYM were prolonged with progression of HIV infection, while in non-ART, G-6-PD and APTT were decreased with HIV progression as depicted by decreased CD4 count.