Structural basis of a unique interferon-[beta] signaling axis mediated via the receptor IFNAR1

Nicole Anne De Weerd,Julian P. Vivian,Thao Kim Thi Nguyen,Niamh E. Mangan,Jodee A. Gould,Susie-Jane Braniff,Leyla Zaker-Tabrizi,Ka Yee Fung,Samuel C. Forster,Travis Clarke Beddoe,Hugh H. Reid,Jamie Rossjohn,Paul J. Hertzog

Structural basis of a unique interferon-[beta] signaling axis mediated via the receptor IFNAR1

2013

Nicole Anne De Weerd
Julian P. Vivian
Thao Kim Thi Nguyen
Niamh E. Mangan
Jodee A. Gould
Susie-Jane Braniff
Leyla Zaker-Tabrizi
Ka Yee Fung
Samuel C. Forster
Travis Clarke Beddoe
Hugh H. Reid
Jamie Rossjohn
Paul J. Hertzog

Type I interferons regulate immune responses by signaling via heterodimeric IFNAR1-IFNAR2 complexes. Hertzog and colleagues reveal a unique IFN-β–IFNAR1 signaling complex that is IFNAR2-independent and modulates expression of a distinct set of interferon-inducible genes.

Keywords:

Cell biology
Immunology
Immune system
Biology
Interferon
Gene
Receptor
interferon beta

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