Experimental study of eliminat dampness resolv phlegm method in treating cervical spondylopathy of the vertebral artery type

Objective:To detect the velocity and viscosity of blood flow of the vertebral arteries,the apoptotic cell and apoptotic related protein in the brain in order to offer theoretical foundation for the treatment of cervical spondylopathy of the vertebral artery type with the eliminat dampness resolv phlegm method.Methods:Sixty male Japanese big ear rabbits were divided randomly into normal sodium group(A),Flunarizine group(B),low dosage Wendantang(温胆汤)group(C),large dosage Wendantang(温胆汤) group(D),Flunarizine group combined with large dosage Wendantang(温胆汤) group(E),normal group(F).Each group had 10 rabbits.Xiaozhiling injection was injected around the vertebral arteries of rabbits in group A,B C,D,E to make the model of the cervical spondylopathy of the vertebral artery type.Normal sodium(20 ml·kg-1d-1) was apply through intragastric administration in group A,F;Flunarizine(0.8 mg·kg-1d-1),low dosage Wendantang(温胆汤,1 g·ml-1d-1),large dosage Wendantang(温胆汤,2 g·ml-1d-1),Flunarizine combined with large dosage Wendantang(温胆汤) were respectively apply through intragastric administration in group B,C,D,E.The velocity and viscosity of blood flow of the vertebral arteries,the apoptotic cell and apoptotic protein in the brain were detected before and after the treatment.Results:Satisfactory animal model were obtained in group A,B,C,D,E.The rabbits of group E had the most improvement of the velocity and viscosity of blood flow of the vertebral arteries while at meantime,which had the lowest apoptotic index and apoptotic related protein expression in the brain.Conclusion:The routine treatment for the cervical spondylopathy of the vertebral artery combined with eliminat dampness resolv phlegm method could improve velocity and viscosity of blood flow of the vertebral arteries,which maybe relate with reduction of apoptosis in the brain.