Generalized model of polypeptide chain for helix-coil transition in two-component solvent

Within the frameworks of Generalized Model ofPolypeptide Chain (GMPC) the influence of the ligands interacting by different ways in the helix-coil transition is studied. It is shown that the model is reduced to the base model by converting the energy and the entropic parameters. In contrast to the case of the pure solvent, both the competitive and the noncompetitive interactions affect to these parameters. As a result, the temperature curve of melting shows more transitions. The influence of polyethylene glycol on the helix-coil transition in the polyalanine is discussed.