Increase Activity of Superoxide Dismutase in Adults Sprague- Dawley Rats Liver After Exposed To Bisphenol A

Bisphenol A (BPA) has been reported to process hepatic toxicity. We investigated the hypothesis that BPA can induce reactive oxygen species (ROS) by increasing oxidative stress in the liver. The dosing solutions were prepared by thoroughly and uniformly mixing BPA in corn oil at 0, 2, 10, 50 mg/kg body weight/day, were administered intraperitoneally every forty-eight hours for 20 days to adults Sprague-Dawley rats. After 24 h of the last treatment, rats were weighed, sacrificed and organs harvested for analysis. The body weight of treated rats did not show significant change as compared with the corresponding control groups. In BPA treated rats there was a significant decrease in the weight of liver organ. Suggesting that there was not a linear relationship between liver weight and body weight during the treatment, suggesting that comparisons made in terms of relative organ weights do not necessarily take proper account of differences in body weight. The activity of antioxidant enzyme superoxide dismutase (SODs) in liver tissue significantly increased in all groups treated with BPA when compared to the control group suggesting uncontrolled overproduction of ROS and failure in antioxidant system. The results indicated that BPA induces oxidative stress in the liver of rats by increasing activity of SOD. These findings provide a possible toxicological evidence of an adverse effect of BPA on liver damage.