A Multifunctional Smart Soft Contact Lens Device Enabled by Nanopore Thin Film for Glaucoma Diagnostics and In Situ Drug Delivery

In this paper, we report a new power-free multifunctional soft contact lens device that can measure intraocular pressure (IOP), achieve extended drug delivery in situ , and detect glaucoma biomarkers, all within the same device. Experiments demonstrate that the contact lens sensor can detect Interleukin 12p70, one possible biomarker for glaucoma, in a concentration as low as 2 pg/ml in artificial tears. The sustained drug release of the contact lens device can last up to 30 days. In ex vivo tests using cadaver pig eyes, the sensor detected IOP in a range of 10–50 mmHg with excellent repeatability. [2019-0067]