A Study on Kalladaippu

AIM AND OBJECTIVES: AIM: The aim of my dissertation work is to evaluate the efficacy of the trial drug, Megarajangachooranam both clinically and experimentally in the treatment of kalladaippu. OBJECTIVES: 1. To collect the authoric measures and literature reviews of Kalladaippu noi in ancient siddha and modern literatures. 2. To have an idea of the incidence of the disease with regard to age, sex, occupation , socio economic status, food, climatic conditions and precipitating factors etc. 3. To expose the efficacy of siddhar’s diagnostic principles. 4. To utilize the possible methods to confirm the diagnosis and prognosis. 5. To have clinical trial on patients with kalladaippu noi with selected siddha medicine. • Megarajanga chooranam (Athmaratchamirtham). 6. To evaluate: Toxicological screening • Acute. • Sub acute. 7. Pharmacological screening • Lithotriptic 8. To find out the statistical analysis of clinical study. SUMMARY: I like to summarize this study with the following highlights. • Males are more prone to get kalladaippu than females according to my studies. • In age distribution, 3rd and 4th decades of people are more affected. • Housewifes and manual workers occupy the first two places in occupational classification. • All of my patients, had mixed dietary habits. • Higher incidence of cases were noted in Elavenir kaalam (April – June). • In the disturbance of Ezhu udal thathukkal, 100% were affected by saaram, 22.5% were affected by senneer and 5% were affected by Enbu. • In Naadi, most of the patients were having pitha vadha naadi and vadhapitha naadi. • In Neikuri examination 57.5% were having pithaneer. • All of my patients were having urinary presentation, 95% were having loin pain, 77.5% had burning micturition, 40% had dysuria. 30% had nausea, 12.5% had vomiting, 7.5% had retention and haematuria. • Most of the 40 patients, had stone in kidney (ie) Bothsides of urinary system is affected in majority of 57.5%. • All of my patients were administered with my trial medicine Megarajanga chooranam – 1 gm bd with butter after food for a period of 48 days. After treatment with this trial medicine most of the symptoms like loin pain, burning micturition and dysuria are relieved by the expulsion of the stone. And the trial medicine shows 62.5% good result. CONCLUSION: Kalladaippu is a common disorder of Pithakuttram. The dearranged pitham is settled down by the trial medicine having suvai Inippu thereby the medicine acts as Ethirurai maruthuvam to cure the disease. • Most of the cases noted in kaarkalam, ilavenir kaalam in my clinical trial. So, people should take all preventive measures during this period and take enough water. • Toxicological studies showed no acute or subacute toxicity. • Pharmacological study reveals that the trial medicines possess diuretic as well as lithotriptic actions. • During the clinical trial, no adverse reactions or complications were observed. • The palatability of the trial drug is sweet, so it is easier to consume to the patients. • The trial medicine Megarajanga chooranam showed good results with the expulsion of stone in few patients and relieve urinary symptoms in almost 90% of patients. • Once again siddha medicine proves itself as a great boon to mankind.