Synthesis and Pharmacological Characterization of Some 2- and 1,2-substituted Benzimidazoles

Taking into account the important role of ultraviolet radiation in premature skin aging and cancer, 2- and 1,2substituted benzimidazoles were synthesized, whole molecules contain conjugated chromophores and may produce strong absorption at wavelengths convenient for being photo protectors. 4 different benzimidazoles were used, of which 2 were never mentioned in the literature. The four compounds are characterized from the physical point of view, especially from a spectral perspective. To assess the acute toxicity of the four compounds (symbolized as S1, S2, S3 and S4), white male mice from the NMRJ strain were used, grouped in 4 groups, of 10 individuals each. The highest lethality was induced by the S3 compound (20%). To assess motor activity, 6 groups of 10 white NMRJ mice were used. Compounds S2, S3 and S4 display a central stimulating effect, highlighted by the evolution of vertical motor activity. Compound S3 caused the greatest percentage increase in horizontal and vertical motor activity compared to the reference. The toxicity of synthetized compounds was tested phytobiologically on Triticum aestivum caryopses (Triticum test). As a result of testing, a decreasing order of toxicity was noted: S3 , S2, S1 and S4.