Synthesis, Crystal Structures and Urease Inhibition of N'-(2-Bromobenzylidene)-2-(4-nitrophenoxy) acetohydrazide and N'-(4-Nitrobenzylidene) -2-(4-nitrophenoxy)acetohydrazide.

Two new hydrazone compounds, N' -(2-bromobenzylidene)-2-(4-nitrophenoxy)acetohydrazide ( 1 ) and N' -(4-nitrobenzylidene)-2-(4-nitrophenoxy)acetohydrazide ( 2 ), were prepared and structurally characterized by elemental analysis, IR, UV-Vis and 1 H NMR spectroscopy, and single-crystal X-ray diffraction. Compound 1 crystallizes in the monoclinic space group P 2 1 / n with unit cell dimensions of a = 5.3064(5) A, b = 18.202(2) A, c = 15.970(2) A, β = 95.866(3)o, V = 1534.4(2) A 3 , Z = 4, R 1 = 0.0457, and wR 2 = 0.0975. Compound 2 crystallizes in the monoclinic space group P 2 1 / c with unit cell dimensions of a = 4.6008(7) A, b = 14.451(2) A, c = 23.296(3) A, β = 93.620(2)o, V = 1545.8(4) A 3 , Z = 4, R 1 = 0.0441, and wR 2 = 0.0985. Structures of the compounds are stabilized by hydrogen bonds and π···π interactions. The urease inhibitory activities of the compounds were studied. Both compounds show strong urease inhibitory activities, with IC 50 values of 8.4 and 20.2 μM, respectively.