Optimal TLR9 signal converts tolerogenic CD4–8– DCs into immunogenic ones capable of stimulating antitumor immunity via activating CD4+ Th1/Th17 and NK cell responses

TLR ligands have been reported to promote DC maturation and enhance CD8 CTL responses. We have demonstrated previously that CD4 – 8 – DCs secreting TGF- stimulate CD4 Tr1 cell responses. Here, we