The expression of tumor suppressor CYLD in specific neoplasias

The tumor suppressor CYLD is a deubiquitinating enzyme that acts as a negative regulator of several signaling pathways including NF-kappa-B and MAPK activation pathways, by affecting the function of important mediators. CYLD regulates several cellular processes such as immune responses, inflammation, cell survival, proliferation and differentiation. The tumor suppressor function of CYLD seems to be cell-type specific and it is important to delineate its involvement in the homeostasis of specific tissues in order to understand and exploit its role in oncogenesis . In this review, we summarize existing data on the expression and alterations of CYLD in certain types of lung and colorectal neoplasias.