Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme (ICE) inhibitors
2006
Abstract An 8,5-fused bicyclic peptidomimetic ring system generated by a stereoselective ring metathesis reaction was elaborated into potent inhibitors of interleukin-1β converting enzyme (ICE, caspase-1). Multiple compounds were found that exhibited ICE IC 50 values 50 values
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