Prevalence and Related Factors for Post-stroke Complex Regional Pain Syndrome: A Retrospective Cross-sectional Cohort Study.

Abstract Objective The objectives of this study were to evaluate the prevalence of post-stroke Complex Regional Pain Syndrome (CRPS) to estimate related factors for post-stroke CRPS in first-ever stroke patients. Design This is a retrospective cross-sectional cohort study of adult patients (age > 18 years) with stroke who were admitted to rehabilitation unit from December 2014 to May 2018 in Korea. Setting Single acute rehabilitation unit of university hospital. Participants Participants were identified from the stroke rehabilitation registry of our institute who have diagnosed with first-ever stoke, which included 313 patients. Interventions Not applicable. Main Outcome Measures Prevalence of post-stroke CRPS based on clinical features and three-phase bone scintigraphy and the related factors of post-stroke CRPS. Results A total of 313 records were analyzed including demographic, clinical characteristic, and functional variables. Post-stroke CRPS was found in 8.94% (28/313) patients with first-ever stroke. Logistic regression analysis showed Fugl Meyer Assessment of Upper Extremity (FMA-UE) score was a significant associated factor for the presence of CRPS (odds ratio, 0.96; 95% CI, 0.94–0.98; P=.003). The cut-off value of 76 point for FMA-UE score yielded moderate accuracy in identifying of post-stroke CRPS (92.6% sensitivity, 65.8% specificity, and 0.85 area under the curve). Conclusions The prevalence of post-stroke CRPS was 8.94% in first-ever stroke patients. The FMA-UE score was associated with the post-stroke CRPS. Therefore, in patients with low FMA-UE score, prevention and high suspicion of post-stroke CRPS is necessary.