The justification for application and development trends of non-conventional rodenticides in protection of alfalfa from rodents.

This paper presents the harmful rodents in alfalfa in Serbia in the first decade of this century. We also review the products registered and assessed the efficiency of conventional (acute) rodenticides, anticoagulant and rodenticides based on environmentally friendly active ingredients. In addition to anticoagulants of second generation, whose mechanism of action is based on a synthesis of the factors preventing blood coagulation, in the latest of the eighties, and in early of nineties introduced products based on vitamin D3-cholecalciferol. Their mechanism of action is based on the mobilization of calcium from bone and tissue and calcification of blood vessels, kidney, liver, heart muscle leading to delays in the work of these bodies. The last decade of the last century have been recorded and products based on trace element selenium (Se), the mechanism of action is based on the replacement of thiol functional enzymes SS groups. Also presents the possibility of application of ecological cellulose product in the field. In the world, so far, cellulose based rodenticides are only registered in municipal buildings. Its mechanism of action is based on interference with the absorption of water leading to dehydration in rodents. Rodents do not develop resistance to products based on vitamin D3 and selenium, a cellulose product is favourable toxicological and eco-toxicological point. [Projekat Ministarstva nauke Republike Srbije, br. III 46008: Development of integrated management system harmful organisms in crop production in order to overcome resistance and improve the quality and safety of food]