Developmental blockage of mouse embryos caused by fatty acids

Purpose It has been shown that lipid peroxides derived from polyunsaturated fatty acids (PUFAs) inhibit the proliferation of various cells. In the meantime, it has been suggested that oxidative stress is closely related to the developmental blockage of mammalian embryos cultured in vitro. In this study, we investigated the effects of various fatty acids on mouse embryo development in vitro, and the reversal of these effects by various antioxidants such as Superoxide dismutase, ascorbic acid, α-tocopherol, uric acid, and ethylenediaminetetraacetic acid.