The formulation and evaluation of Disodium cromoglycate dry powder inhaler mixtures using the Rotahaler device

Inhalation of drugs offers the opportunity to treat diseases of the respiratory tract. In this drug delivery mode, the use of dry powder inhalers is preferred compared to pressurized metered dose inhalers. Metered dose inhalers contain chlorofluorocarbons known to affect the environment adversely. In this study we have formulated inhalation mixtures containing disodium cromoglycate using modified lactose. The effect of a proprietary method used to smoothen the surface of the modified lactose used  as carrier for drug in the inhalation mixtures was determined with the ROTAHALER TM  device and the Twin Impinger Apparatus BP. The respirable fraction obtained was higher in inhalation mixtures containing modified lactose compared to mixtures containing regular lactose, the control. Keywords : dry powder inhalers, respirable fraction, disodium cromoglycate, Rotahaler device, Twin Impinger BP Journal of Pharmaceutical and Allied Sciences , Vol. 7 No. 3 (2010)