Advances and prospects in adoptive cell transfer therapy for ovarian cancer

Despite recent advances in targeted therapies, epithelial ovarian cancer (EOC) remains the most lethal form of gynecologic malignancy. Thus, improving the clinical outcome of patients will require reinvestment in research development and further clinical investigation. T-cell accumulation in EOC is prognostic for survival and recent advances in adoptive T-cell therapy now provide a renewed opportunity to specifically modulate T-cell number and activity in EOC and mediate tumor regression. Here, we discuss the application of adoptive T-cell transfer based immunotherapy and its prospects for the treatment of EOC.