Toxicological study of the high-explosive formulation imidazo(4,5-d)imidazole-2,5(1H,3H)-dione, tetrahydro-1,4-dinitro

The acute oral LD/sub 50/ values for the high-explosive formulation imidazo(4,5-d)imidazole-2,5(1H,3H)-dione, tetrahydro-1,4-dinitro (DINGU) for mice and rats are greater than 5 g/kg. According to classical guidelines, the mixture would be considered only slightly toxic or practically nontoxic in both species. Skin application studies in the rabbit with DINGU demonstrated that it was cutaneously nonirritating. This material was also nonirritating in rabbit eye application studies. The sensitization study in the guinea pig did not show DINGU to be deleterious in this regard.