Impact of passive immunity induced by maternal vaccination on subsequent immunization and disease-sparing in early-weaned beef calves challenged with highly virulent BVDV

Vaccination programs have been developed to limit disease associated with bovine viral diarrhea virus (BVDV) infection. The ultimate goal of BVDV vaccination is to induce immunity that prevents viral replication after infection; however, passively acquired BVDV-specific neutralizing antibodies can impact immunity and vaccine responses in the young calf. The purpose of this study was to examine the impact of passively-derived antibody on vaccine response and mitigation of disease in early weaned beef calves whose passive immune status was documented, and when vaccination and challenge were separated by only 5 days.