Impact of the Liquid Part and Some Separate Components of Blood on the Process of Interaction between Yersinia pestis EV NIIEG Bacteria and Human Red Blood Cells in vitro

Objective of the research has been the evaluation of impact of blood liquid part and its separate protein fractions on the process of Yersinia pestis EV NIIEG adhesion to human erythrocytes in vitro . Bacterial binding with target-cells has been registered using photometric technique. Identified has been inhibiting effect of blood native plasma and serum, as well as some groups of serum proteins, (albumins and normal immunoglobulins) on attachment of bacteria to human red blood cells. Based on the obtained results it has been assumed that there are two possible mechanisms of suppression of Yersinia pestis EV NIIEG adhesion to human erythrocytes performed by the liquid components of blood – surface microbial structure blockage and erythrocyte membrane receptor shielding.