0027. Kinetic of muscle mass regulation during experimental sepsis

Sepsis induced muscle weakness (SIMW) is associated with an important morbidity of critical care patients. Moreover, respiratory muscles weakness delays weaning from mechanical ventilation. The down-regulation of Akt pathway and the activation of proteolytic pathways, such as ubiquitin-proteasome or autophagy-lysosome pathways, could play a key role in the pathogenesis of SIMW. However, the kinetic response of these pathways is currently unknown.