Phenylpropanoid derivatives from Clausena harmandiana fruits

Abstract A new phenylpropanoid derivative, harmandianone ( 1 ), along with four known compounds: verimol B ( 2 ), ( E )-3-(2-hydroxy-4-methoxy-phenyl)propanoate ( 3 ), ( E )-methyl p -coumarate ( 4 ), and ( E )-5-methoxy-2-(prop-1-enyl)phenol ( 5 ) was isolated from the acetone extract of Clausena harmandiana fruits. All structures were characterized by spectroscopic methods (UV, IR, NMR and ESI-TOF-MS). Compounds 1 and 3 – 5 demonstrated weak antibacterial activity against Escherichia coli TISTR 780, methicillin-resistant Staphylococcus aureus SK1, Salmonella typhimurium TISTR 292 and S. aureus TISTR1466, with MIC values between 64 and 128 μg/mL.