Replication B Inhibits Gammaherpesvirus Lytic κ NF

Nasopharyngeal carcinoma, Kaposi’s sarcoma, and B-cell lymphomas are human malignancies associatedwith gammaherpesvirus infections. Members of this virus family are characterized by their ability to establishlatent infections in lymphocytes. The latent viral genome expresses very few gene products. The infected cellsare therefore poorly recognized by the host immune system, allowing the virus to persist for long periods oftime. We sought to identify the cell-specific factors that allow these viruses to redirect their life cycle fromproductive replication to latency. We find that the cellular transcription factor NF-