Role of Helicobacter pylori in gastric diseases pathogenesis cannot be ignored.

We read with interest the study by Guo et al , evaluating the risk of gastrointestinal bleeding (GIB) in aspirin users after Helicobacter pylori eradication.1 It revealed a higher risk of GIB in new aspirin users even after H. pylori eradication than chronic aspirin users as well as non-users. The propensity score matching method was also performed to balance the potential differences of baseline characteristics among groups, which largely compensate for the deficiencies of retrospective research. However, the prevalence of H. pylori infection among Chinese population remains high (40%–60%).2 3 We hope to explicitly demonstrate the relationship between H. pylori infection and gastric diseases to justify the necessity of H. pylori eradication. In our recent retrospective study, a …