Novel High-Drug-Loaded Amorphous Dispersion Tablets of Posaconazole; In Vivo and In Vitro Assessment.

Deanna M. Mudie,Aaron M. Stewart,Nishant Biswas,Timothy J. Brodeur,Kimberly B. Shepard,Adam J. Smith,Michael Morgen,John M. Baumann,David T. Vodak

Novel High-Drug-Loaded Amorphous Dispersion Tablets of Posaconazole; In Vivo and In Vitro Assessment.

2020

Deanna M. Mudie
Aaron M. Stewart
Nishant Biswas
Timothy J. Brodeur
Kimberly B. Shepard
Adam J. Smith
Michael Morgen
John M. Baumann
David T. Vodak

Amorphous solid dispersions (ASDs) can increase the bioavailability of drugs with poor aqueous solubility. However, concentration-sustaining dispersion polymers (CSPs) incorporated in ASDs can resu...

Keywords:

Bioavailability
Posaconazole
In vivo
Dispersion (optics)
Amorphous solid
Dissolution testing
Drug
Materials science
Area under the curve
Biomedical engineering

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