Use of modifier as trapping fluid in preparative supercritical fluid chromatography

Abstract A commercial supercritical fluid chromatograph has been adapted for preparative SFC. A simple fractionating and collection system which can use the liquid supercritical fluid modifier as a trapping is described. The fractionation of polycarboxylic acid mixtures is used to illustrate the technique. Acids, isolated and obtained in this way, were of a purity close to 100%. The effect on recovery rates of using additonal liquid collection solvent in the collection vessels and of surrounding them with a dry ice jacket was investigated.