Maclafungin, a New Antifungal Macrocyclic Lactone from Actinomycete sp. Y-8521050.

Abstract A new antifungal macrocyclic lactone maclafungin, belonging to the oligomycin class has been isolated from an actinomycete sp. Y-8521050. The antibiotic, having a molecular formula of C 46 H 80 O 12 , is active against several fungal species. Its structure was elucidated by analysis of 2D NMR experiments.