Diagnostik primär kutaner B-Zell-Lymphome

Primary cutaneous B-cell lymphomas (PCBL) are rare skin tumors. The three major subtypes are the indolent variants primary cutaneous follicle centre lymphoma (PCFCL) and primary cutaneous marginal zone lymphoma (PCMZL), and the more aggressive PCBCL primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL, LT). After a nodal lymphoma with secondary skin involvement has been excluded by staging procedures, the differentiation between the subtypes is in most cases possible by the medical history, clinical examination and (immuno)-histochemical analysis. However, in some cases molecular analyses are required to achieve diagnosis.