Comparison of CKD-EPI estimated glomerular filtration rate and measured creatinine clearance in critically ill patients with normal plasma creatinine

Introduction: Accurate assessment of renal function is a priority in the management of critically ill patients. Assessment of renal function helps in guiding drug dosing, optimize fluid, acid–base, and electrolyte management. Evidence based medicine in the form of research studies have shown that there exists a poor correlation between CKD-EPI eGFR and creatinine clearance in patients with normal plasma creatinine. Currently there is a paucity of data in India as to whether examining whether eGFR could be used in place of conventional measures for such a purpose, particularly in the critical care environment. The study was done to compare CKD-EPI eGFR with measured urinary CLCR, in recently admitted critically ill patients with normal plasma creatinine concentrations. Material and Methods: The study was a prospective observational study which consisted of recently admitted critically ill patients with normal plasma creatinine concentrations admitted to the ICU of A. J. Institute Of Medical Sciences Hospital, Mangalore on f 100 patients who met a pre-defined criteria done over a period of 2 years from October 2014 to November 2016 after obtaining ethical clearance committee of the institution and informed consent of the patient and/or their legal heir. This was a prospective observational study that was conducted in the intensive care unit Patients who were recently were admitted to the intensive ICU admission, plasma creatinine concentration