Epithelial Abnormalities: Glandular

As is well known, cervical cytology is primarily a screening test for squamous intraepithelial lesions and squamous cell carcinoma; the relative sensitivity of the test for the detection of glandular lesions can be limited by issues related to both sampling and interpretation. However, continued advancement of the understanding of cervical glandular carcinogenesis and refinement of the cytomorphologic criteria has led to greater sensitivity and precision in the interpretation of these lesions. Improved communication among laboratories and clinicians has ensued, thereby facilitating the appropriate management of patients. This chapter provides important general background information regarding neoplastic glandular lesions and details the morphologic criteria and terminology necessary for accurate interpretation. An expanded discussion of morphologic mimics with aids to correct identification and classification is updated from the prior (2004) edition. Current management guidelines for glandular lesions presenting in Pap tests are also highlighted.