Single electron transistor based nanosensor for DNA and RNA detection
2020
Detection and sequencing of DNA and RNA nucleobases are of immense usefulness for next-generation medical diagnostics and forensic investigation. In this work, we have proposed a novel single electron transistor (SET) based detection methodology, exploring the detection sensitivity, temperature range of operation, etc. Extensive first-principle based calculations were used to investigate the operation, electrostatics, and quantum transport behavior of the SETs in single and double-gated structures over a wide range of source–drain bias ( V d) and gate voltage ( V g). It was observed that the double-gated SET offers better electrostatic control and energy efficient operation compared to the single gated SET. Various line scans taken from the charge stability diagrams are labeled to the presence of individual nucleobases as demonstrated in the normalized differential conductance behavior. The present method offers label free biosensing and nanoelectronic sensor design in an energy efficient architecture, which can be used for other biological applications as well.
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