Formulation and In-Vitro evaluation of fast dissolving tablets of telmisartan

Telmisartan is a Anti-hypertensive drugs which is i nsoluble in water, hence the drug may be slowly or incompletely dissolves in the gastro-intestinal tract. So the ra te of dissolution and therefore its bioavailability is less (bioavailability 42%). In the present study an atte mpt has been made to prepare Fast Dissolving tablet s of Telmisartan by using Superdisintegrants‐ Cross carmellose sodium, Microcrystalline cellulose and sodiu m starch glycolate, level of addition to increase the rate o f drug release from dosage form to increase the dis solution rate and hence its bioavailability. The tablets were prepare d by Direct Compression methods and the prepared blend and tablets were evaluated for their physicochemical pr operties and In-Vitro dissolution study. The evalua tion studies were performed such as Weight Variation, Thickness, Hardness, Disintegrating Time, Wetting Time, and I n-Vitro Drug Release. The Disintegration time of Fast Disso lving tablets were increased by the addition of con centration of Superdisintegrants.