Synthesis method of 9-desoxy-9-homoerythromycin A(Z) oxime

The invention discloses a synthesis method of 9-desoxy-9-homoerythromycin A(Z) oxime, which comprises the following steps: adding 9-desoxy-9-homoerythromycin A(E) oxime into an organic solvent, wherein the mass-volume ratio of the 9-desoxy-9-homoerythromycin A(E) oxime to the organic solvent is 1g:(3-10)ml; stirring until the 9-desoxy-9-homoerythromycin A(E) oxime is completely dissolved, and adding an alkali, wherein the mole ratio of the 9-desoxy-9-homoerythromycin A(E) oxime to the alkali is 1:(0.2-1.0); stirring at 0-5 DEG C for 64-82 hours; and after the reaction finishes, filtering, washing the obtained filter residue with a 0-5-DEG C organic solvent to obtain a white solid, and carrying out vacuum drying on the white solid to obtain the 9-desoxy-9-homoerythromycin A(Z) oxime finished product. The method is very simple in technical process and very convenient to operate. The synthesized 9-desoxy-9-homoerythromycin A(Z) oxime has the advantages of high purity, no color change and high yield.