Identification and optimisation of a 4',5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors.

Abstract Exploring the affinity-pocket binding moiety of a 2-aminothiazole ( S )-proline-amide-urea series of selective PI3Kα inhibitors using a parallel-synthesis approach led to the identification of a novel 4′,5-bisthiazole sub-series. The synthesis and optimisation of both the affinity pocket and ( S )-proline amide moieties within this 4′,5-bisthiazole sub-series are described. From this work a number of analogues, including 14 (A66) and 24 , were identified as potent and selective PI3Kα inhibitor in vitro tool compounds.