ВЛИЯНИЕ ВИТАМИНОВ ГРУППЫ В НА РАННЕЕ РАЗВИТИЕ КРЫСЯТ С ПРЕНАТАЛЬНОЙ ГИПЕРГОМОЦИСТЕИНЕМИЕЙ

High plasma homocysteine levels - hyperhomocysteinemia (hHCy), are considered as an independent risk factor for early abortion of pregnancy, placental abruption, preeclampsia, and other complications. One of the factors of hHCy development is a deficiency of vitamins B. At the same time, both deficiency and excess of B vitamins can induce neurotoxic effects and oxidative stress. The aim of our work was to analyze the treatment of rats with hHCy with vitamins B during pregnancy on the early development and glutathione level in plasma of the offspring. In the offspring of rats with hHCy we observed high mortality, reduced body weight, increased concentrations of homocysteine and reduced glutathione level in plasma, and a delay in the development of sensory-motor reflexes and different types of behavior analyzed in the Open Field and Rotarod tests. Administration of vitamins B (B6,9,12) to pregnant rats with hHCy led to lower mortality and higher body weight of the offspring, increased level of glutathione, and partial prevention of sensory-motor deficit of the offspring. At the same time, we observed decreased plasma homocysteine levels, which, however, did not reach the control values. Positive effects of vitamins B on the level of anxiety and muscle strength of animals with prenatal hHCy were observed. However, the horizontal motor activity, rearing, motor balance were not restored. Thus, despite positive effects of vitamins B therapy on the physical development and the formation of sensory-motor reflexes, the impairments of motor coordination in complex behavior acts were not prevented, which may be explained by the fact that plasma homocysteine levels were not restored to the control values and/or the inability of the B vitamins completely neutralize the consequences of chronic hHCy.