Targeting Oncogenes Which Regulate Apoptosis

Characterization of the genetic changes driving the malignant phenotype has revealed that mutations promoting cell survival are common in human cancer. The increased understanding of cancer at the molecular level has lead to the development of therapeutics aimed at inhibiting the function of the genes responsible for the tumor phenotype. Inhibition of the activity of the oncogenes promoting tumor cell survival is an attractive approach for the development of cancer therapeutics that has already yielded some success and promises more.