Preparation method for dalfampridine

The invention relates to a preparation method for dalfampridine. The preparation method comprises the following steps: 1) preparing isonicotinic acid amide resin from amino resin and isonicotinic acid through a coupler; 2) removing the resin by virtue of a lysis solution and preparing isonicotinic acid amide; and 3) performing Hofmann degradation on isonicotinic acid amide obtained in the step 2) through a degrading reagent and alkali to obtain dalfampridine.