Research Paper A Facile Synthesis and Cytotoxicity of a Novel Porp hyrin-Cryptolepine Conjugate
2012
A novel porphyrin-cryptolepine conjugate 7 with a 1,2,3-triazole linker was synthesized by the cycloaddition reaction of propargyl porphyrin 2 and azido cryptolepine 6 under click conditions. The conjugate 7 exhibited enhanced photocytotoxicity against A549 cells with IC 50 values of 2.5 µM and 7.9 µM in the visible and UV light, respectivel y.
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