The Effect of Busuishengxue Granule on the Level of Phosphorylated AKT in CAA Patients' Bone Marrow

Objective: To observe the effect of Busuishengxue Granule on the level of Phosphorylated AKT in CAA patients' bone marrow,and to explore the mechanism of Busuishengxue Granule on CAA.Methods: 30 CAA patients were treated with Busuishengxue Granule for 6 months,and another 10 healthy volunteers as normal control group.Use Western blot method(Western-blot) to observe the expression of PAKT-Ty308 in CAA patients' bone marrow mononuclear cells before and after treatment.Results: The expression of PAKT-Ty308 in CAA patients' bone marrow mononuclear cells were lower than that of normal control group(P0.05),and the expression of PAKT-Ty308 was on the rise after treatment,so the comparison was significant difference before treatment.Conclusion: The expression of PAKT-Ty308 in CAA patients' bone marrow takes on low levels,so it suggests that PAKT is closely related to the pathogenesis of CAA,and Busuishengxue Granule may regulate the expression of PAKT-Ty308 to improve the CAA bone marrow microenvironment.