AN OVERVIEW ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM

Gastro retentive drug delivery system can be retained in the stomach for long time by formulating. The development of Gastro retentive drug delivery system is to control physiological adversities such as short gastric residence times and unpredictable gastric emptying time. Differences in gastric physiology such as gastric pH and motility exhibit both intra and inter subject variability demonstrating significant impact on gastric residence time and drug deliver. Several approaches are done for drug delivery systems such as, swelling and expanding systems, bio-adhesive systems, modified shape systems, high density systems or other delayed gastric emptying devices have been discovered till now.