Metabolic and ultrastructural changes in the myocardium after prolonged exposure to low concentrations of carbon disulfide

: The authors studied the changes in myocardium during a long-term effect of low carbon sulphide concentrations--50 and 10 mg/m3 by enzyme-histochemical, biochemical and classical histological and electron microscopic methods. THe data from the experiment provided evidence of the involvement of myocardium and vessels in destructive-adaptation reactions in case of carbon-sulphide effect, the destructive processes being with preponderance. They are conditioned both by metabolic disorders of energy-forming systems and the disturbed processes of transport and utilization of energy. Furthermore, the action coordination is disturbed as in the separate muscle cells and the totality of the tissue elements, forming the myocardium as well.