Carcinogenesis of Intraductal Papillary Mucinous Neoplasm of the Pancreas: Loss of MicroRNA-101 Promotes Overexpression of Histone Methyltransferase EZH2

Osamu Nakahara,Hiroshi Takamori,Masaaki Iwatsuki,Yoshifumi Baba,Yasuo Sakamoto,Hiroshi Tanaka,Akira Chikamoto,Kei Horino,Toru Beppu,Keiichiro Kanemitsu,Yumi Honda,Ken Ichi Iyama,Hideo Baba

Carcinogenesis of Intraductal Papillary Mucinous Neoplasm of the Pancreas: Loss of MicroRNA-101 Promotes Overexpression of Histone Methyltransferase EZH2

2012

Osamu Nakahara
Hiroshi Takamori
Masaaki Iwatsuki
Yoshifumi Baba
Yasuo Sakamoto
Hiroshi Tanaka
Akira Chikamoto
Kei Horino
Toru Beppu
Keiichiro Kanemitsu
Yumi Honda
Ken Ichi Iyama
Hideo Baba

Background The mechanisms of IPMN carcinogenesis are as yet unclear. This study aimed to determine whether expression of EZH2 promotes neoplastic progression of IPMN and PDCA, and to elucidate regulation of EZH2 expression by miR-101.

Keywords:

Pathology
Neoplastic progression
microRNA
EZH2
Laser capture microdissection
Intraductal papillary mucinous neoplasm
Histone methyltransferase
Carcinogenesis
Cancer research
Medicine
Pancreas
Pancreatic cancer
Immunohistochemistry

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