Fatal lactic acidosis associated with tenofovir

Borges, Marco A V Ferreira, Francisco J F Silva, Andre J C RPereira,Francisca M Abreu,Simone M Lugao (Instituto Munici-pal Philippe Pinel, Rio de Janeiro); Marcelo P C P Santos,Marcio Gewandsznajder, Valeria R P Mercadante (HospitalMunicipal Jurandyr Manfredini, Rio de Janeiro); Walmor LangeJr,Carla L Dias (Instituto Municipal de Assistencia a Saude Niseda Silveira,Rio de Janeiro).The members of the TREC SteeringCommittee and Data Monitoring Committee are listed onbmj.com.Contributors:See bmj.comFunding: No participating centre directly received funds forinvolvement in TREC.GH undertook TREC as part of her workfunded by the Ministry of Health, Brazil. TREC was jointlyfunded by Fundacao Osvaldo Cruz, the Cochrane Schizophre-nia Group, the British Council, CAPES (Coordenacao de Aper-feicoamento de Pessoal de Nivel Superior), and FAPERJ(Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro).All salary funding was intramural. Drugs used in the trial weresupplied by the local government through Secretaria Municipalde Saude do Rio de Janeiro. A computer was given by theResource Centre for Randomised Controlled Trials(www.rcrt.ox.ac.uk/).Competing interests:None declared.Ethical approval: TREC was approved by ethics committeesfrom Escola Nacional de Saude Publica Fundacao OswaldoCruz, Instituto Phillipe Pinel, and Hospital Municipal JurandyrManfredini, Instituto Municipal de Assistencia a Saude Nise daSilveira and by the members of the Consumer Advocate Groupof Rio de Janeiro (SOSINTRA—Society of family and friends ofthe mentally ill in Rio de Janeiro). TREC was also approved bythe National Council of Ethics in Research.