A case of Angiosarcoma not recognizing metastasis for about 3 year by IL-2 administration.

A 62-year-old man visited our clinic for the treatment of a domeshaped tumor on his left frontal scalp. The histopathology of the biopsied lesion showed angiosarcoma. He was treated with surgical operation. 11 months later, the recurrence of the tumor from the center of the skin graft was observed. The recurrent lesion was treated with surgical operation and intralesional injection of recombinant interleukin 2 (rIL-2). There was no evidence of the local recurrence or metastasis during 18 months after the surgical excision. But iliac bone metastasis was noted with low back pain and confirmed by CT scan.Metastatic bone lesion was treated by electron beam irradiation combined with systemic intravenous injection of rIL-2.8 months later the patient died of respiratory failure. We guessed that the combination therapy of rIL-2 and surgical excision should improve the cure rate of angiosarcoma.