Mapping Hypoxia in Renal Carcinoma with Oxygen-enhanced MRI: Comparison with Intrinsic Susceptibility MRI and Pathology

Ross Little,Yann Jamin,Jessica K.R. Boult,Josephine H. Naish,Yvonne Watson,Susan Cheung,Katherine Holliday,Huiqi Lu,Damien J. McHugh,Joely J Irlam,Catharine M L West,Guy N J Betts,Garry Ashton,Andrew R. Reynolds,Satish B. Maddineni,Noel W. Clarke,Geoff J.M. Parker,John C. Waterton,Simon P. Robinson,James P B OConnor

Mapping Hypoxia in Renal Carcinoma with Oxygen-enhanced MRI: Comparison with Intrinsic Susceptibility MRI and Pathology

2018

Intrinsic susceptibility imaging and immunohistochemistry analysis were used to validate a combined endpoint of oxygen enhancement plus MR-derived perfusion as a biomarker of tumor hypoxia in mouse and patient studies.

Keywords:

Carcinoma
Radiology
Pathology
Hypoxia (medical)
Biomarker (medicine)
Perfusion
Medicine
Tumor hypoxia
Kidney
Magnetic resonance imaging
Immunohistochemistry
oxygen enhanced

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