TranSyT, the Transport Systems Tracker

The importance and rate of development of GSM models have been growing for the last years, increasing the demand for software solutions that automatise several steps of this process. However, since TRIAGE9s release, software development for automatic integration of transport reactions into models has stalled. Here we present the Transport Systems Tracker (TranSyT), the next iteration of TRIAGE. Unlike its predecessor, TranSyT does not rely on manual curation to expand its internal database, derived from highly-curated records retrieved from TCDB and complemented with information from other data sources. TranSyT compiles information regarding TC families, transport proteins, and derives reactions into its internal database, making it available for rapid annotation of complete genomes. All transport reactions have GPR associations and can be exported with identifiers from four different metabolite databases. TranSyT is currently available as a plugin for merlin v4.0 and an app for KBase.