Study of the Effect of the Expression of bFGF in Tranfected bcl-2 Gene Therapy of Cerebral Ischemia in Rat

Objective To study the protective effct of bcl-2 against neuroal injury and the possible roles of alteration in the expression of bFGF following cerebral ischemia in rat.Methods 150 wistar rats were randomly assingned in 3 groups(bcl-2 treated group,saline group and pLXSN group),there were 50 rats in each group.And we studied the bFGF expression in 3,6,24,48,72hours after MCAO temporary ischemia of the MCAO for 2 hours was induced.Results The expression of bFGF in the saline group and pLXSN group weren't different in each time(P0.05),bFGF expressed early in the bcl-2 group and lasted for a long time,while its expression was more than other groups at the same time.Conclusion Bcl-2 can effectivly attenuate ischemic brain injury and increase the expression of bFGF in the ischemic brain,indicating that the neuroprotective of estrogen is associated with up-regulation of bFGF in cerebral ischemia.